Humectant ingredient
DNA
DNA (deoxyribonucleic acid) in cosmetics refers to isolated and purified DNA — often from salmon milt (salmon sperm) as a sustainable byproduct — used as a humectant and skin-conditioning active. The phosphate backbone of DNA binds water strongly, delivering surface hydration and a moisturizing film. Low-molecular-weight depolymerized fractions may have skin conditioning benefits. Distinct from medical-grade PDRN (polydeoxyribonucleotide), which is a specific fraction with tissue-regeneration activity administered by injection.
Also known as: depolymerized DNA, hydrolyzed DNA
humectantskin-conditioningfilm-forming
Benefits
- ✓High molecular weight DNA acts as a hydrating film-former on the skin surface, binding water through its phosphate backbone and providing an immediate moisturizing effect
- ✓Low molecular weight/hydrolyzed DNA fractions are absorbed more readily and may participate in cellular recognition processes supporting skin renewal
- ✓Used in premium Korean and European skincare as an intensive hydrating and skin-conditioning active; distinct from medical-grade PDRN (polydeoxyribonucleotide) used in aesthetic injections
Watch for
- ⚠Typically sourced from salmon milt (salmon sperm) — not vegan; individuals with fish allergy should exercise caution
- ⚠Should not be confused with PDRN (polydeoxyribonucleotide) treatments used in aesthetic medicine — topical cosmetic DNA does not penetrate to the cellular level to function as PDRN does
Compatibility
✓ Works well with
+ Sodium Hyaluronate+ Glycerin+ Adenosine+ Beta-Glucan
