Active ingredient
Trifluoroacetyl Tripeptide-2
Trifluoroacetyl Tripeptide-2 (sequence TFA-Val-Tyr-Val; trade name Progeline™, Lucas Meyer Cosmetics/IFF; CAS 64577-63-5) is an anti-senescence signal peptide that targets progerin — a truncated lamin A splice variant that accumulates in aging fibroblasts and drives cellular senescence. Reducing progerin slows the molecular aging program while simultaneously inhibiting MMP-1/-3/-9 and elastase, upregulating syndecan-1, and activating the Nrf2 antioxidant pathway. Clinical trials at 4 ppm (8 weeks) showed +20% firmness and +20.9% elasticity with measurable reduction in jawline sagging. Used at extremely low concentrations (0.0004–0.002%) in premium anti-aging serums and ampoules.
Also known as: Progeline, Progeline FF
skin-firminganti-senescenceanti-agingskin-conditioning
Benefits
- ✓Reduces progerin synthesis in aging fibroblasts by ~18–22% — progerin is the truncated lamin A protein that accumulates in mature skin cells and drives cellular senescence, slowing the molecular aging program at the gene level
- ✓Inhibits collagenase (MMP-1/-3) and elastase degradation of structural fibers — in vitro data shows ~43% protection against collagenase and ~100% protection against elastase at the use concentration
- ✓Clinical data (4 ppm, 8 weeks): +20% skin firmness, +20.9% elasticity, reduced jawline sagging volume — plus upregulation of syndecan-1 in keratinocytes and TGF-β signaling enhancement
No known watch-fors.
Compatibility
✓ Works well with
+ Acetyl Tetrapeptide-2+ Palmitoyl Tripeptide-5+ Copper Tripeptide-1+ Niacinamide+ Sodium Hyaluronate
