The library

Ingredient library

Every ingredient SkinAtlas knows about — all 2161 of them. What each one does, what it works well with, and what to watch for.

49 ingredients in Active matching "peptide" — page 1 of 3

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Active
Acetyl Dipeptide-1 Cetyl Ester

A synthetic dipeptide-cetyl ester (trade name Lumiskin/Calmosensine) that modulates the skin's endorphin pathway to deliver soothing and anti-aging benefits.

peptideanti-aging
Mimics the opioid-pathway signal that triggers skin repairMay improve firmness and skin texture
Active
Acetyl Heptapeptide-4

A synthetic seven-amino-acid peptide (Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala; trade name Fensebiome™) that acts as a microbiome-modulating active, strengthening the skin's barrier and defence against pathogens rather than acting on neuromuscular SNARE pathways.

skin conditioninghumectantmicrobiome supportbarrier support
Supports skin microbiome balance by promoting growth of beneficial bacteriaReinforces the skin's physical and microbial barrier functionReduces sensitivity and irritation in urban/stressed skin
Active
Acetyl Hexanoyl Dipeptide-3 Norleucine
ACETYL HEXANOYL DIPEPTIDE-3 NORLEUCINE

A synthetic dipeptide derivative with a hexanoyl and acetyl modification. Has melanogenesis-inhibiting properties for skin brightening. Used in Ishizawa's urea face cream.

anti-agingskin-brightening
Inhibits melanin synthesis — skin brighteningAnti-aging dipeptide
+ Niacinamide+ Tranexamic Acid
Active
Acetyl Hexapeptide-1

A synthetic hexapeptide (trade name Melitane) that activates the alpha-MSH receptor pathway to stimulate melanin synthesis and support an even skin tone.

peptideanti-aging
Stimulates melanin production to improve uneven toneMarketed for a healthy-glow effect
May worsen hyperpigmentation, melasma, or other conditions of excess pigmentation — acts as an MC1R agonist that actively stimulates melanin synthesis; not appropriate for those prone to dark spots or uneven darkening
Active
Acetyl Hexapeptide-38
ACETYL HEXAPEPTIDE-38

A biomimetic hexapeptide that stimulates lipid accumulation in dermal adipocytes (fat cells). Used in anti-aging products to restore facial volume and firmness. Found in Minon's aging care products.

anti-agingskin-firmingskin-conditioning
Stimulates lipid synthesis in adipocytes — volumizing and plumping effectAnti-aging — counteracts facial volume lossImproves skin firmness
+ Hyaluronic Acid+ Niacinamide
Active
Acetyl Hexapeptide-4

A synthetic six-amino-acid peptide used in premium Korean skincare formulas for its skin-conditioning and anti-aging properties. Distinct from Acetyl Hexapeptide-8 (Argireline) and from Acetyl Heptapeptide-4 (Fensebiome).

peptideskin-conditioninganti-aging
Synthetic hexapeptide with skin-conditioning and anti-aging claimsUsed in barrier-repair and anti-wrinkle formulas
+ Ceramide NP+ Panthenol
Active
Acetyl Octapeptide-3

An 8-amino-acid acetylated peptide (trade name SNAP-8), the extended version of Acetyl Hexapeptide-3. Acts as a neurotransmitter inhibitor that relaxes facial expression muscles, providing a topical anti-wrinkle mechanism similar to botulinum toxin. Used in premium K-beauty peptide ampoules.

anti-agingmuscle-relaxinganti-wrinkle
Inhibits neurotransmitter release at the neuromuscular junction, reducing repeated facial tensionLonger peptide chain than Acetyl Hexapeptide-3 — may offer enhanced efficacyVisibly smooths expression lines with regular use
+ Acetyl Hexapeptide-8+ Palmitoyl Pentapeptide-4+ Copper Tripeptide-1
Active
Acetyl Tetrapeptide-11

A synthetic signaling tetrapeptide that upregulates syndecan-1 and Collagen XVII expression in keratinocytes, supporting skin barrier cohesion and firmness.

peptideanti-agingcell-communicatingskin-conditioning
Stimulates synthesis of syndecan-1 to strengthen cell adhesion and skin barrierPromotes Collagen XVII production to improve skin firmness and elasticitySupports dermal-epidermal junction integrity for a smoother, more cohesive skin texture
Active
Acetyl Tetrapeptide-2

Acetyl Tetrapeptide-2 (ac-KDVY; trade names Peptigravity, Uplevity, Thymulen-4 by Lipotec/BASF) is a biomimetic signal peptide derived from the thymopoietin hormone sequence. Its principal mechanism is upregulation of the elastin assembly pathway — specifically FBLN5 and LOXL1, proteins required to cross-link tropoelastin into mature elastic fibers — alongside collagen I/IV/VI/XIV stimulation and MMP inhibition. Peer-reviewed AFM studies (PMC6208634) confirm dose-dependent increases in keratinocyte cell stiffness and upregulation of ACTN1, ITGB4, and COL17A1. Used at 0.005–2% in serums, ampoules, and eye creams targeting firmness and skin density loss.

skin-firmingskin-conditioningelastin-boostinganti-aging
Signal peptide that upregulates elastin assembly proteins Fibulin-5 (FBLN5) and Lysyl Oxidase-Like 1 (LOXL1), restoring the cross-linking of tropoelastin into functional elastic fibers — the primary mechanism behind its anti-sagging and firming activityStimulates collagen type I, IV, VI, and XIV gene expression in fibroblasts, plus COL17A1 (collagen XVII) in keratinocytes for strengthened dermal-epidermal junction integrityIncreases keratinocyte and fibroblast adhesion to the ECM via focal adhesion pathway proteins (zyxin, integrin, talin), and inhibits MMPs that degrade collagen — providing structural density and resistance to gravity-related tissue laxity
+ Palmitoyl Tripeptide-5+ Copper Tripeptide-1+ Sodium Hyaluronate
Active
Argireline
Acetyl Hexapeptide-8

A peptide marketed to relax expression lines.

peptide
Targets expression lines
Active
Copper Peptides
Copper Tripeptide-1

A signaling peptide that supports skin repair and firmness.

peptide
Supports collagenWound healingImproves firmness
× Ascorbic Acid× Glycolic Acid
Active
Dipeptide Diaminobutyroyl Benzylamide Diacetate

A synthetic dipeptide that acts as a reversible antagonist at muscular nicotinic acetylcholine receptors, reducing repetitive facial muscle contractions to smooth expression lines.

anti-wrinkleneuromuscular-blocking-peptide
Mimics venom peptide waglerin-1 to inhibit acetylcholine receptors at the neuromuscular junction, reducing muscle-contraction-driven expression linesSmooths fine lines and wrinkles with continued useWell tolerated at typical cosmetic concentrations
Insufficient long-term topical safety data; avoid in pregnancy as a precaution
Active
Dipeptide-15

A synthetic dipeptide of two glycine residues (glycylglycine) used as a skin- and hair-conditioning agent in cosmetic formulations.

skin-conditioninghair-conditioning
Conditions and smooths skin surfaceSupports skin rejuvenation as part of peptide complexes
Active
Hexapeptide-2

A six-amino-acid peptide that acts as an alpha-MSH antagonist, blocking one of the key signals that triggers melanin synthesis in melanocytes.

skin-brighteningpeptidemelanogenesis-inhibitor
Competes with alpha-MSH (melanocyte-stimulating hormone) to reduce melanin productionHelps even skin tone and reduce the appearance of dark spots
+ Niacinamide+ Oligopeptide-68
Active
Hexapeptide-9

A synthetic matrikine hexapeptide (Gly-Pro-Gln-Gly-Pro-Gln) that mimics a collagen sequence to stimulate extracellular matrix protein synthesis and support skin regeneration.

activeanti-agingskin-conditioning
Stimulates fibroblasts to increase collagen type I and IV productionEnhances hyaluronic acid synthesis in the dermisImproves skin firmness, elasticity, and texture
Active
Matrixyl
Palmitoyl Pentapeptide-4

A signal peptide marketed to support collagen and firmness.

peptide
Targets fine linesSupports firmness
+ Niacinamide
Active
Nonapeptide-1

A synthetic nonapeptide (9-amino-acid sequence) functioning as an alpha-MSH antagonist; it blocks the melanocyte-stimulating hormone receptor to reduce melanin synthesis, used as a skin-brightening active.

brighteninganti-pigmentationactive
Inhibits alpha-MSH binding to MC1R receptor to reduce melanin productionInhibits tyrosinase for additional anti-pigmentation effectPromotes a more even, brighter skin tone
Considered safe at cosmetic concentrations; no significant cytotoxicity reportedLong-term topical safety data is limited compared to established brightening agents
Active
Oligopeptide-1

A synthetic tripeptide composed of glycine, histidine, and lysine (GHK) that acts as a copper-binding signal peptide, stimulating collagen and glycosaminoglycan synthesis in fibroblasts and supporting skin repair and anti-aging.

activeskin-conditioninganti-aging
Stimulates collagen and glycosaminoglycan synthesis in fibroblastsHelps reduce the appearance of fine lines and wrinklesSupports skin repair and wound healing
Generally well-tolerated at cosmetic concentrations; rare skin sensitization possible
Active
Oligopeptide-2

A synthetic lysine-serine-threonine oligopeptide that functions as a skin conditioning and signal peptide, activating the skin's endogenous repair mechanisms to support anti-aging activity.

skin-conditioninganti-agingsignal-peptide
Short-chain synthetic peptide (lysine oligomer with serine and threonine) that signals skin's endogenous repair mechanismsSupports skin regeneration, structural integrity, and visible wrinkle reductionDistinct from sh-Oligopeptide-2 (recombinant IGF-1 analog) — a simpler synthetic oligopeptide
Active
Oligopeptide-4

A synthetic tetrapeptide (four amino acids) that acts as a signal peptide in cosmetics, stimulating skin's natural repair processes to improve firmness, elasticity, and reduce visible aging.

skin-conditioninganti-agingsignal-peptide
Synthetic tetrapeptide that signals skin to activate endogenous repair mechanismsStrengthens skin structure and reduces visible fine lines and wrinklesImproves skin elasticity and overall complexion
Active
Oligopeptide-6
OLIGOPEPTIDE-6

A synthetic hexapeptide that mimics the activity of EGF (epidermal growth factor). Stimulates cell proliferation and collagen synthesis, contributing to skin firming and anti-aging benefits. Used in Lululun's Hydra EX mask.

anti-agingskin-firmingskin-conditioning
Growth factor-mimetic peptideStimulates collagen and elastin synthesisAnti-aging and firming
+ Hyaluronic Acid+ Niacinamide
Active
Oligopeptide-68

A synthetic oligopeptide that targets tyrosinase — the key enzyme in melanin production — making it a precision brightening active suited for dark spots and uneven tone.

skin-brighteningtyrosinase-inhibitorpeptide
Inhibits tyrosinase to reduce melanin synthesis and brighten hyperpigmentationWorks at the cellular level for even-toned, luminous skin
+ Niacinamide+ Ascorbic Acid
Active
Palmitoyl Dipeptide-10

A synthetic signal peptide composed of palmitic acid, alanine, and histidine that provides antioxidant protection, inhibits glycation, and supports skin barrier function with a well-tolerated safety profile.

peptideantioxidantanti-glycation
Neutralizes collagen-degrading enzymesInhibits advanced glycation end-products (AGEs)Supports skin barrier function and moisture retention
Active
Palmitoyl Hexapeptide-12

A signal peptide used to support firmness and a smoother, conditioned skin surface.

peptide
Supports firmnessConditioning
+ Matrixyl+ Copper Peptides
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